Back Pain Can Affect Almost Everything You Do.
Back pain can make ordinary activities — standing, walking, lifting, working, sleeping or caring for family — more difficult.
Pain Relief International believes pain relief is more than comfort. When pain becomes a barrier to everyday activity, reducing that barrier can create greater opportunity for movement, independence, work and participation in daily life.
Back Pain Can Reshape an Entire Day.
Back pain can influence how people move, sleep, work and manage ordinary responsibilities. Its effects can extend into family life, employment and participation in the community.
Movement
Standing, walking, bending, lifting and even changing position can become more difficult when the back hurts.
Work
Back pain can interfere with physically demanding jobs as well as work that requires prolonged sitting or standing.
Sleep & Recovery
Finding a comfortable position can be difficult, and disrupted sleep can add another burden to an already painful day.
Daily Life
Household tasks, driving, recreation, caregiving and family activities may all become harder when movement is painful.
The Burden of Back Pain Can Spread Beyond One Person.
When pain limits someone's ability to work, move or manage everyday responsibilities, family members, coworkers and caregivers may have to help carry the load.
Greater opportunity for movement, independence, sleep and everyday activity.
Potentially less assistance needed with transportation, household tasks and everyday responsibilities.
Greater opportunity to remain active, present and productive at work.
More opportunity for people to participate, contribute and remain connected to everyday life.
A Different Approach to Pain Relief
The PRI 4×4 Deployment Unit uses NeuroCuple® technology — a passive, nonpowered approach to pain relief built around a patented array of capacitive junctions.
The technology is designed to interact through non-invasive capacitive coupling with the local bioelectrical environment associated with pain perception.
NeuroCuple does not deliver powered electrical stimulation into the body. It requires no batteries, charging, wires or medication, and it does not require direct skin contact.
For lower-back pain, position the unit over the area where pain is being experienced. It can be repositioned as needed and may be used over clothing or dressings.
What Has NeuroCuple Been Studied For?
NeuroCuple technology has been evaluated in clinical research, including randomized studies involving patients undergoing total knee and hip arthroplasty.
Important Context for Back Pain
The published clinical studies cited by Pain Relief International evaluated NeuroCuple technology in postoperative orthopedic populations. Those studies provide clinical evidence for the technology, but they should not be interpreted as direct clinical proof of effectiveness for nonspecific back pain.
Back pain can have many causes. Pain Relief International therefore separates the published clinical evidence for the technology from claims about conditions that have not yet been directly evaluated in those studies.
Experience It Yourself. Help Bring Relief to Others.
The PRI 4Ă—4 Deployment Unit gives you an opportunity to experience the same durable, reusable, drug-free technology used by Pain Relief International in its humanitarian work.
Keep it available when pain becomes a barrier. The unit requires no batteries, charging or consumables and can be repositioned when needed.
You receive your own reusable PRI 4Ă—4 Deployment Unit. 100% of proceeds from device purchases fund Pain Relief International deployments to help expand access to pain relief.
Please note: purchasing a device is not a tax-deductible donation.
When Pain Is Reduced, the Possibilities Can Spread Outward.
Around the world, pain can become a barrier to work, education, caregiving, independence and participation — especially where access to pain treatment is limited.
Pain Relief International works to expand access to practical, reusable, drug-free pain relief in homes and communities. You can experience the technology yourself, make a charitable contribution, or do both.
Remove the Pain. Unleash the Possibilities.®
Back Pain Relief Without Medication
What are some drug-free approaches to back pain?
Depending on the cause and circumstances, drug-free approaches may include appropriate activity and exercise, physical therapy, rehabilitation strategies and nonpowered pain-relief technologies. New, severe, persistent or unexplained back pain should be evaluated by an appropriate healthcare professional.
What is NeuroCuple®?
NeuroCuple is a passive, nonpowered pain-relief technology built around an array of capacitive junctions designed to interact through non-invasive capacitive coupling with the local bioelectrical environment associated with pain perception. It requires no drugs, batteries, charging or wires.
Where is the PRI 4Ă—4 positioned for lower-back pain?
Position the unit over the area where the pain is being experienced. The unit can be repositioned as needed to help identify the placement that works best for the individual.
Does NeuroCuple require direct skin contact?
No. The PRI 4Ă—4 Deployment Unit can be positioned over the area of pain and may be used over clothing or dressings.
Has NeuroCuple been clinically studied for back pain?
The published clinical studies cited here evaluated NeuroCuple technology in postoperative orthopedic populations, including total knee and hip arthroplasty. Those studies should not be interpreted as direct clinical proof of effectiveness for nonspecific back pain.
Does the PRI 4Ă—4 use batteries or electricity?
The device is passive and nonpowered. It requires no batteries, charging or wires and does not deliver powered electrical stimulation into the body.
Can the PRI 4Ă—4 be reused?
Yes. The PRI 4Ă—4 Deployment Unit is reusable and designed to be kept available and repositioned when needed.
How much does the PRI 4Ă—4 Deployment Unit cost?
The PRI 4Ă—4 Deployment Unit is $80. You receive your own reusable unit, and 100% of proceeds from device purchases fund Pain Relief International deployments. Purchasing the device is not a tax-deductible donation.
Evidence & Sources
- World Health Organization. Low back pain. World Health Organization
- Klatt BA, O'Malley M, Ayazbekova A, et al. Nanotechnology-Based Device Reduces Pain and Immediate Opioid Requirements and Facilitates Earlier Discharge From the Hospital Following Total Knee Arthroplasty: A Randomized Placebo-Controlled Trial. The Journal of Arthroplasty. 2026. DOI: 10.1016/j.arth.2026.04.083. PubMed
- Chelly JE, Klatt BA, Groff Y, et al. Role of the NeuroCuple Device for the Postoperative Pain Management of Patients Undergoing Unilateral Primary Total Knee and Hip Arthroplasty: A Pilot Prospective, Randomized, Open-Label Study. Journal of Clinical Medicine. 2023;12:7394.
This page is provided for educational purposes and is not intended to diagnose a medical condition or replace professional medical care. Back pain can have many causes. Seek appropriate medical evaluation for new, severe, persistent or unexplained pain, pain following significant injury, or pain accompanied by concerning neurological or other symptoms.